Ioana Stãnculescu
Assistant Professor dr.

 

Teaching:
 
 

Molecular Structure
(course, laboratory, IInd  year, B.Sc. Chemistry-Physics and Radiochemistry)

Informatics Applied in Chemistry
(course, IIIrd  year, B.Sc. Radiochemistry)

Informatics Applied in Chemistry - in french
(course, IIIrd  year, B.Sc. Chemistry)

Molecular Interactions - in french
(laboratory, VIth  year, M.Sc. Synthèse, Structure et Reactivité Appliquées à la Chimie des Médicaments)
 
 
 
 
 
 
 

Research:










DOMAINS OF INTEREST:

* Physical Chemistry
* Methods of Molecular Structure Study: molecular spectroscopy (FTIR, UV-Vis, fluorescence, EPR, NMR) and molecular modeling (molecular and quantum mechanics methods)
 

CURRENT PROJECTS:

* IR and NMR spectroscopy of alkali and alkali earth complexes of natural compounds with pharmacological properties
* UV-Vis absorption and fluorescence spectroscopy of drugs: metallic ion complexes
* Molecular modeling applied to the study of: sterols auto-association, ester-oxalate based chemiluminescence, drug-metallic ion, drug-sterol and drug-nucleic acids complexes
 
 

Recent Publications:


 
    1. Books:

    2. 1. "Interactions moléculaires"
      C. Mandravel and I. Stãnculescu
      Ed. Universitãtii din Bucuresti, Bucharest (2004)
    3.  
    4. 2. "Structurã molecularã"
      V. Chiosa, I. Stãnculescu and C. Mandravel
      Ed. Universitãtii din Bucuresti, Bucharest (2006)
    5.  


    1. Articles:

    2. 1. "ORD and conformational study on some new cholesteric compounds"
      M. Chivu, I. Baciu, V. Chiosa, I. Stãnculescu, C. Bendic, C. Popescu and C. Mandravel
      Anal. Univ. Buc. Ser. Phys., 125-130, (2000)
    3.  
    4. 2. "Some contributions to the study of electrochemical properties and electronic structure of tetrandrine"
      C. Mandravel and I. Stãnculescu
      Ann. West Univ. Tim. Ser. Chem., 10, 961-962 (2001)
    5.  
    6. 3. "Electronic structure of some cholesterol derivatives"
      C. Bendic, C. Popescu, V. Chiosa, I. Stãnculescu and C. Mandravel
      Anal. Univ. Buc. Ser. Chem., X(1), 19-25 (2001)
    7.  
    8. 4. "IR variable temperature spectroscopy (I). Hydrogen bonding in 1,2,3,4- tetrahydronapthalil hydroperoxide"
      C. Mandravel, M. Deacu and I. Stãnculescu
      Anal. Univ. Buc. Ser. Chem., XI(1), 97-100 (2002)
    9.  
    10. 5. "IR variable temperature spectroscopy and theoretical study concerning decomposition of 1,2,3,4-tetrahydronaphtalil hydroperoxide"
      C. Mandravel and I. Stãnculescu
      Rev. Roum. Chim., 47(1-2), 63-66 (2002)
    11.  
    12. 6. "Theoretical study on the pharmacophore properties of some bisbenzylisoquinoline alkaloids as calcium channel blockers"
      C. Mandravel and I. Stãnculescu
      Rev. Roum. Chim., 47, 799-804 (2002)
    13.  
    14. 7. "Etude par resonace magnetique nucleaire sur les complexes de la tetrandrine avec l'ion de calcium. L'influence de l'anion de couplage"
      I. Stãnculescu, G. Surpãteanu, D. Landy, P. Woisel and C. Mandravel
      J. Univ. Chem. Tech. Metall., XXXVIII, 121-128 (2002)
    15.  
    16. 8. "Complexation of tetrandrine with calcium ion probed by various spectroscopic methods and molecular modeling"
      I. Stãnculescu, C. Mandravel, D. Landy, P. Woisel and G. Surpãteanu
      J. Mol. Struct., 655, 81-87 (2003)
    17.  
    18. 9. "Cation binding characteristics of tetrandrine studied by UV-Vis absorption and fluorescence spectroscopies"
      I. Stãnculescu, C. Mandravel, F. Delattre, D. Landy, P. Woisel and G. Surpãteanu
      J. Photochem. Photobiol. A, 161, 79-85 (2003)
    19.  
    20. 10. "IR spectral and modeling study concerning an antisilicotic drug: L-aluminium lactate"
      I.G. Bratu, V. Chiosa, I. Stãnculescu, D. Zaharia and C. Mandravel
      Anal. Univ. West Tim., Ser. Chem., 12(3), 1-10 (2003)
    21.  
    22. 11. "Total Assignment and structure in solution of tetrandrine by NMR spectroscopy and molecular modeling"
      A. Thevand, I. Stãnculescu, C. Mandravel, P. Woisel and G. Surpãteanu
      Spectroch. Acta A, 60, 1825-1830 (2004)
    23.  
    24. 12. "Actual trends in computational toxicology I. Using physical-chemical data to evaluate the acute toxicity (LD50)"
      C. Mandravel, V. Chiosa and I Stãnculescu
      Anal. Univ. Buc. Ser. Chem., XIII (I-II), 229-232 (2004)
    25.  
    26. 13. "IR spectral and theoretical study concerning the nature of oligomeric association forms in some sterols solutions. II. Cholestanol"
      V. Chiosa, C. Teodoreanu, I. Stãnculescu and C. Mandravel
      Anal. Univ. Buc. Ser. Chim., XIV, 247-252 (2005)
    27.  
    28. 14. "IR spectral and theoretical study concerning the nature of oligomeric association forms in some sterols solutions. II. Cholesterol"
      C. Mandravel, V. Chiosa, C. Teodoreanu and I. Stãnculescu
      Rev. Roum. Chim., 50 (7,8), 683-688 (2005)
    29.  
    30. 15. "Molecular modeling of some chemiluminescent systems used as cold light devices"
      C. Mandravel, I. Stãnculescu, V. Chiosa, C. Tutuianu and A. Gimiga
      Ann. West Univ. Tim., Ser. Chem., 14 (1), 67-76 (2005)
    31.  
    32. 16. "The reactivity and biological activity of some iridoid glycosides"
      A. Bleotu, I. Stãnculescu and C. Mandravel
      Ann. West Univ. Tim., Ser. Chem., 14 (2), 215-220 (2005)
    33.  
    34. 17. "Experimental and theoretical study of the ethacridine lactate-an antiseptic remedy"
      V. Chiosa, G. Bratu and I. Stãnculescu
      Ann. West Univ. Tim., Ser. Chem., 14(2), 173-178 (2005)
    35.  
    36. 18. "Comparison of QSPR properties for cholesterol and cholestanol oligomeric association forms"
      V. Chiosa, C. Mandravel, C. Teodoreanu and I. Stãnculescu
      Rev. Roum. Chim., in press, (2005)
    37.  


      Conferences:

    1. 1. "Various IR Techniques Spectral Study of a Panacea Herb Origin: Tetrandrine"
      C. MANDRAVEL and I. STÃNCULESCU
      23-rd American Romanian Academy Congress, Rochester, NY, USA (1998)
    2.  
    3. 2. "Molecular Modeling Study of Tetrandrine (in Romanian)"
      C. MANDRAVEL, G. SURPATEANU, I. STANCULESCU and V. CHIOSA
      XXV-th Nat. Ses. Chem, alimanesti-Caciulata, Romania (1999)
    4.  
    5. 3. "A conformational study on cholesteric compounds"
      I. Stanculescu, M. Chivu, C. Bendic, C. Mandravel
      2-nd Int. Conf. Chem. Soc. South - Eastern European Countries, Halkidiki, Greece (2000)
    6.  
    7. 4. "Molecular Modeling with the MM3 Method of an Antitoxic Drug-Tetrandrine"
      I. STANCULESCU, V. CHIOSA and C. MANDRAVEL
      10-th Conf. Phys. Chem., Iasi, Romania (2000)
    8.  
    9. 5. "Electronic Structure of Some Cholesterol Derivatives"
      C. BENDIC, C. POPESCU, I. STANCULESCU and C. MANDRAVEL
      10-th Conf. Phys. Chem, Iasi, Romania (2000)
    10.  
    11. 6. "Spectropolarimetric and Electronic Structure Study of Some Cholestanol Derivatives"
      I. STANCULESCU, M. CHIVU, I. BACIU, C. BENDIC, V. CHIOSA and C. MANDRAVEL
      XIIth Rom. Int. Conf. Chem. Chem. Eng., Bucharest, Romania (2001)
    12.  
    13. 7. "Electrochemical Studies of Some Properties Involving the Charge Transfer for Naphtoquinonic Chlorinated Derivatives"
      I. IOSUB, C. BOSCORNEA, V. CHIOSA and I. STANCULESCU
      Proc. 27-rd Ann. Congr. Amer. Rom. Acad. Arts Sciences, Romania (2002)
    14.  
    15. 8. "Complexation of Tetrandrine with Calcium Ion Studied by Different Spectroscopic Methods and Molecular Modeling (in Romanian)"
      C. MANDRAVEL, G. SURPATEANU, I. STANCULESCU, D. LANDY and P. WOISEL
      XXVIII-th Nat. Ses. Chem, Calimanesti-Caciulata, Romania (2002)
    16.  
    17. 9. "Interaction between Quartz and an Antisilicotic Drug - Aluminium Lactate - A Molecular Modeling Study"
      I.G. BRATU, I. STANCULESCU, D. ZAHARIA, V. CHIOSA and C. MANDRAVEL
      XIII-th Rom. Int. Conf. Chem. Chem. Eng., Bucharest, Romania (2003)
    18.  
    19. 10. "Tetrandrine as Host Partner in Molecular Recognition Phenomenon. Experimental and Theoretical Study on the Complexation of Tetrandrine with Calcium Cation"
      I. STANCULESCU, C. MANDRAVEL, F. DELATTRE, D. LANDY, S. FOURMENTIN, P. WOISEL and G. SURPATEANU
      Int. El. Conf. Mol. Design, (2003)
    20.  
    21. 11. "Tendances modernes dans la toxicologie II. Prédiction de la toxicité sévère (LD50) basée sur les propriétés physico chimiques et modélisation moléculaire"
      C. MANDRAVEL, V. CHIOSA, R. ENE and I STANCULESCU
      3-ème Colloque Franco-Roumain de Chimie Appliquée, Romania (2004)
    22.  
    23. 12. "Modélisation moléculaire appliquée aux quelques processus essentiels dans le métabolisme du cholestérol"
      7. I. STANCULESCU, V. CHIOSA, C. POPESCU-TEODOREANU, I.G. BRATU, N. TOPOLEANU and C. MANDRAVEL
      3-ème Colloque Franco-Roumain de Chimie Appliquée, Romania (2004)
    24.  
    25. 13. "Modelling of European/Chinese Mechanism Remedy of silicosis: Aluminium lactate or Tetrandrine"
      I.G. BRATU, V. CHIOSA and I. STANCULESCU
      4-th Int. Conf. Chem. Soc. South - Eastern Eur. Countries, Belgrade, Serbia and Montenegro (2004)
    26.  
    27. 14. "Molecular Modeling in Complex Chemiluminescent Systems Containing Ester-Oxalates"
      I. STANCULESCU, C. TUTUIANU, A. GIMIGA, C. MANDRAVEL
      30-rd Ann. Congr. Amer. Rom. Acad. Arts Sciences, Chisinau, Moldova (2005)
    28.  
    29. 15. "IR Spectral and Theoretical Study Concerning the Nature of Oligomeric Association Forms in Some Sterols Solutions. III. Comparison on Cholesterol/Cholestanol Behaviour"
      V. CHIOSA, I. STANCULESCU and C. TEODOREANU
      30-rd Ann. Congr. Amer. Rom. Acad. Arts Sciences, Chisinau, Romania (2005)
    30.  
    31. 16. "Modelling of Some Iridoid Glycosides with Anti-Inflammatory Activity"
      A. BLEOTU, I. STANCULESCU and C. MANDRAVEL
      Proc. XIV-th Rom. Int. Conf. Chem. Chem. Eng, Bucharest, Romania (2005)
    32.  
    33. 17. "Molecular Modeling Concerning Some Associated Cholesterol and Cholestanol Species with Potential Metabolic Importance"
      V. CHIOSA, I. STANCULESCU, C. TEODOREANU and C. MANDRAVEL
      XIV-th Rom. Int. Conf. Chem. Chem. Eng, Bucharest, Romania (2005)
    34.  
    35. 18. "Structure of Tetrandrine Complexes with Calcium and Magnesium Ions Described by Molecular Modeling"
      I. STANCULESCU, D. LANDY, C. MANDRAVEL and G. SURPATEANU
      XXII-th Int. Chem. Conf. Coord. Chem., Kishinev, Moldova (2005)
    36.  
    37. 19. "Spectral and Molecular Modelling Study Concerning Interaction of Cholesterol with 2-Pyridine Aldoxime Methylchloride (2-PAM)"
      V. CHIOSA, M. MANEA, GH. RAJU, I. STANCULESCU
      Int. Conf. Young Res, Kishinev, Moldova (2005)
    38.  
    1. Publications list last revised: Tuesday, 28 March 2006 at 15:00:20

     


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